COMPARATIVE EFFECTS OF BORIC ACID AND RESVERATROL ON MCF-7 BREAST CANCER CELLS METASTATIC BEHAVIOUR

Motivation/Background:The metastasis of tumor cells consists steps such as epithelial-mesenchymal transition, transendothelial migration and the formation metastatic colonization. E-Cadherin vimentin are main proteins associated with EMT, whereas MMP-9 is migration.
 Method:We aimed to investigate effects boric acid resveratrol comparatively on metaatatic behaviors MCF-7. 30μM 50μM were administered BA, BA+RES, RES groups 48hours. Cells stained immunocytochemically by Anti-E-Cadherin, Anti-Vimentin, Anti-MMP-9 antibodies H-Score analysis carried out analyzed woundhealing, morphologically.
 Results andConclusions:It’s been observed that doesn’t affect EMT capability MCF-7 in terms expression; whereas, it’s both decreasing expression also inhibiting migration.